Article
Suppression of single and double nonsense mutations introduced into the diphtheria toxin A-chain gene: a potential binary system for toxin gene therapy.
Human gene therapy - 1 Feb 1995
Robinson D F, Maxwell I H
Abstract excerpt
We have previously shown that ablation of specific cells can be achieved through the transcriptionally regulated expression of the diphtheria toxin A-chain (DT-A) gene in both cell culture and transgenic mice. Such targeted toxin gene expression provides a novel approach to cancer and acquired im...
Topics
- Amino Acid Sequence
- Base Sequence
- Diphtheria Toxin
- Gene Expression Regulation
- Genes, Reporter
- Genetic Therapy
- Genetic Vectors
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- RNA, Transfer, Ser
- RNA, Transfer, Tyr
- Suppression, Genetic
- Transfection