Article
Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia.
Molecular and cellular biology - 1 Jun 1996
Mélet F, Motro B, Rossi D J, Zhang L, Bernstein A
Abstract excerpt
The proto-oncogene Fli-1 is a member of the ets family of transcription factor genes. Its activation by either chromosomal translocation or proviral insertion leads to Ewing's sarcoma in humans or erythroleukemia in mice, respectively, Fli-1 is preferentially expressed in hematopoietic and endoth...
Topics
- Animals
- Base Sequence
- Crosses, Genetic
- DNA, Complementary
- DNA-Binding Proteins
- Female
- Friend murine leukemia virus
- Gene Expression Regulation, Developmental
- Gene Rearrangement
- Gene Targeting
- Hematopoiesis
- Homozygote
- Leukemia, Erythroblastic, Acute
- Mice
- Mice, Inbred C57BL