Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder.

doi:10.1038/sj.mp.4000447

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Article

Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder.

Molecular psychiatry - 1 Nov 1998

Turecki G, Grof P, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, Vojtechovský M, Zvolský P, Joober R, Nilsson A, Prochazka H, Licht R W, Rasmussen N A, Schou M, Vestergaard P, Holzinger A, Schumann C, Thau K, Rouleau G A, Alda M

Abstract excerpt

Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1...

Topics

Adult
Age of Onset
Bipolar Disorder
Female
Gene Frequency
Genes, Dominant
Genes, Recessive
Genetic Linkage
Genetic Markers
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Lithium

Lod Score

Male

Middle Aged

Models, Statistical

Phospholipase C gamma

Source

Open in PubMed

Identifiers

PMID: 9857980
DOI: 10.1038/sj.mp.4000447

Genes

PLCG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9857980-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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