Article
Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder.
Molecular psychiatry - 1 Nov 1998
Turecki G, Grof P, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, Vojtechovský M, Zvolský P, Joober R, Nilsson A, Prochazka H, Licht R W, Rasmussen N A, Schou M, Vestergaard P, Holzinger A, Schumann C, Thau K, Rouleau G A, Alda M
Abstract excerpt
Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gamma-1 isozyme of phospholipase (PLC), an enzyme that plays an important role in the...
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