Article
The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness.
Pharmacogenetics - 1 Jun 1998
Steen V M, Løvlie R, Osher Y, Belmaker R H, Berle J O, Gulbrandsen A K
Abstract excerpt
Long-term treatment with lithium salts has been established as an effective prophylactic therapy in manic-depressive (bipolar) illness. Many patients, however, display a lack of (or partial) treatment response. We recently proposed that pharmacogenetic factors may influence and determine the ther...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Bipolar Disorder
- Female
- Forecasting
- Gene Frequency
- Humans
- Israel
- Jews
- Lithium
- Male
- Middle Aged
- Norway
- Phenotype
- Phosphoric Monoester Hydrolases
- Pilot Projects