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Article

Pharmacogenetics of lithium response in bipolar disorder.

Pharmacogenomics - 1 Oct 2010

McCarthy Michael J, Leckband Susan G, Kelsoe John R

Abstract excerpt

Bipolar disorder (BD) is a serious mental illness with well-established, but poorly characterized genetic risk. Lithium is among the best proven mood stabilizer therapies for BD, but treatment responses vary considerably. Based upon these and other findings, it has been suggested that lithium-responsive BD may be a genetically distinct phenotype within the mood disorder spectrum. This assertion has practical...

Topics

Animals
Bipolar Disorder
Genetic Association Studies
Humans
Lithium
Pharmacogenetics
Phenotype
Treatment Outcome

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21047205
DOI: 10.2217/pgs.10.127

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