Article
Long-term responsiveness to lithium as a pharmacogenetic outcome variable: treatment and etiologic implications.
Current psychiatry reports - 1 Dec 2003
Mamdani Firoza, Jaitovich Groisman Iris, Alda Martin, Turecki Gustavo
Abstract excerpt
The importance of genes in the etiology of bipolar disorder has been substantiated through family, twin, and adoption studies. Bipolar disorder is treated at the prophylactic and episodic levels; lithium is one of the most common forms of prophylactic treatment. Recently, pharmacogenetics has come to play an active role in the elucidation of genetic factors that may play a role in modulating lithium response....
Topics
- Antimanic Agents
- Bipolar Disorder
- Brain
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lithium Compounds
- Secondary Prevention
- Treatment Outcome