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Article

pH-dependent growth retardation of Escherichia coli caused by overproduction of Na+/H+ antiporter.

Biological & pharmaceutical bulletin - 1 Nov 1998

Inoue H, Noumi T, Shimomura T, Takimoto N, Tsuchiya T, Kanazawa H

Abstract excerpt

The overproduction of Na+/H+ antiporter NhaA in Escherichia coli caused growth retardation. Quantities and the activity of the antiporter were studied for their causative roles in terms of this retardation. We constructed a series of nhaA-expression plasmids differing in their transcriptional and translational efficiencies. Low-level nhaA expression complemented the defect of an nhaA mutant and allowed the mutant...

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Source

Identifiers

PMID: 9853399
DOI: 10.1248/bpb.21.1128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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pH-dependent growth retardation of Escherichia coli caused by overproduction of Na+/H+ antiporter.PMID 9853399Read ↗

The NhaB Na+/H+ antiporter is essential for intracellular pH regulation under alkaline conditions in Escherichia coli.Semantic proximity Read ↗

A single amino acid substitution (Glu134-->Ala) in NhaR1 increases the inducibility by Na+ of the product of nhaA, a Na+/H+ antiporter gene in Escherichia coli.Semantic proximity Read ↗

NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli.Semantic proximity Read ↗

A point mutation (G338S) and its suppressor mutations affect both the pH response of the NhaA-Na+/H+ antiporter as well as the growth phenotype of Escherichia coli.Semantic proximity Read ↗

Lithium toxicity and Na+(Li+)/H+ antiporter in Escherichia coli.Semantic proximity Read ↗

Identification and characterization of functional residues in a Na+/H+ antiporter (NhaA) from Escherichia coli by random mutagenesis.Semantic proximity Read ↗

The evolution of a Na+-sensitive Vibrio cholerae mutant unmasks the moonlighting aminopeptidase PepA as a regulator of nhaB Na+/H+ antiporter gene expression.Semantic proximity Read ↗

NhaA of Escherichia coli, as a model of a pH-regulated Na+/H+antiporter.Semantic proximity Read ↗

Lysine 300 is essential for stability but not for electrogenic transport of the Escherichia coli NhaA Na+/H+ antiporter.Semantic proximity Read ↗

Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli.Semantic proximity Read ↗

The evolution of a Na <sup>+</sup> -sensitive <i>Vibrio cholerae</i> mutant unmasks the moonlighting aminopeptidase PepA as a regulator of <i>nhaB</i> Na <sup>+</sup> /H <sup>+</sup> antiporter gene expressionSemantic proximity Read ↗

NhaA Na+/H+ antiporter mutants that hardly react to the membrane potential.Semantic proximity Read ↗

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