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Article

The evolution of a Na+-sensitive Vibrio cholerae mutant unmasks the moonlighting aminopeptidase PepA as a regulator of nhaB Na+/H+ antiporter gene expression.

Journal of bacteriology - 20 Aug 2026

Herdan Sebastian, Kohm Katharina, Warneke Robert, Roth Florian, Glaser Nadja, Villani Lucia, Rüping Nele, Dreher Lea, Görge Nicolas, Hoang Trung Duc, Schunke Emina, Häse Claudia C, Rappsilber Juri, Fritz Günter, Commichau Fabian M, Gibhardt Johannes, Steuber Julia

Abstract excerpt

The pathogenic bacterium Vibrio cholerae is aquatic and can be cultivated in nutrient media with increased salt concentration. To maintain osmotic balance, V. cholerae uses Na+/H+ antiporters and a Na+-translocating NADH:quinone oxidoreductase (Na+-NQR). The exact contribution of the various Na+/H+ antiporters to maintaining Na+ and H+ homeostasis in V. cholerae is unclear. However, genetic studies indicate the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42530446
DOI: 10.1128/jb.00155-26
PMCID: PMC13492116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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The evolution of a Na+-sensitive Vibrio cholerae mutant unmasks the moonlighting aminopeptidase PepA as a regulator of nhaB Na+/H+ antiporter gene expression.PMID 42530446Read ↗

The evolution of a Na <sup>+</sup> -sensitive <i>Vibrio cholerae</i> mutant unmasks the moonlighting aminopeptidase PepA as a regulator of <i>nhaB</i> Na <sup>+</sup> /H <sup>+</sup> antiporter gene expressionSemantic proximity Read ↗

Roles of NhaA, NhaB, and NhaD Na+/H+ antiporters in survival of Vibrio cholerae in a saline environment.Semantic proximity Read ↗

Roles of the sodium-translocating NADH:quinone oxidoreductase (Na+-NQR) on vibrio cholerae metabolism, motility and osmotic stress resistance.Semantic proximity Read ↗

A point mutation (G338S) and its suppressor mutations affect both the pH response of the NhaA-Na+/H+ antiporter as well as the growth phenotype of Escherichia coli.Semantic proximity Read ↗

Pharmacophore Based Screening & Modification of Amiloride Analogs for Targeting the NhaP-type Cation-Proton Antiporter in Vibrio choleraeSemantic proximity Read ↗

A single amino acid substitution (Glu134-->Ala) in NhaR1 increases the inducibility by Na+ of the product of nhaA, a Na+/H+ antiporter gene in Escherichia coli.Semantic proximity Read ↗

Mutation E252C increases drastically the Km value for Na+ and causes an alkaline shift of the pH dependence of NhaA Na+/H+ antiporter of Escherichia coli.Semantic proximity Read ↗

Helix VIII of NhaA Na(+)/H(+) antiporter participates in the periplasmic cation passage and pH regulation of the antiporter.Semantic proximity Read ↗

Chemical genomics screening reveals novel functions for unannotated genes in <i>Vibrio cholerae</i> C6706Semantic proximity Read ↗

Transmembrane segment II of NhaA Na+/H+ antiporter lines the cation passage, and Asp65 is critical for pH activation of the antiporter.Semantic proximity Read ↗

<i>Vibrio cholerae</i> OmpR represses the ToxR regulon in response to membrane intercalating agents that are prevalent in the human gastrointestinal tractSemantic proximity Read ↗

NhaA Na+/H+ antiporter mutants that hardly react to the membrane potential.Semantic proximity Read ↗

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