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Article

NhaA Na+/H+ antiporter mutants that hardly react to the membrane potential.

PloS one - 1 Jan 2014

Alkoby Dudu, Rimon Abraham, Budak Maral, Burdak Maral, Patino-Ruiz Miyer, Călinescu Octavian, Fendler Klaus, Padan Etana

Abstract excerpt

pH and Na+ homeostasis in all cells requires Na+/H+ antiporters. The crystal structure, obtained at pH 4, of NhaA, the main antiporter of Escherichia coli, has provided general insights into an antiporter mechanism and its unique pH regulation. Here, we describe a general method to select various NhaA mutants from a library of randomly mutagenized NhaA. The selected mutants, A167P and F267C are described in...

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Identifiers

PMID: 24699187
DOI: 10.1371/journal.pone.0093200
PMCID: PMC3974702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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