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Article

The NhaB Na+/H+ antiporter is essential for intracellular pH regulation under alkaline conditions in Escherichia coli.

Journal of biochemistry - 1 Aug 1994

Shimamoto T, Inaba K, Thelen P, Ishikawa T, Goldberg E B, Tsuda M, Tsuchiya T

Abstract excerpt

We isolated a mutant of Escherichia coli which was defective in an Na+/H+ antiporter and grew poorly under alkaline conditions [Ishikawa, T., Hama, H., Tsuda, T., and Tsuchiya, T. (1987) J. Biol. Chem. 262, 7443-7446]. Later, it was concluded that the defective Na+/H+ antiporter in the mutant was the NhaB system, and the nhaB gene was mapped to 25.6 min on the E. coli chromosome [Thelen, P., Tsuchiya, T., and...

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Identifiers

PMID: 7822245
DOI: 10.1093/oxfordjournals.jbchem.a124521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The NhaB Na+/H+ antiporter is essential for intracellular pH regulation under alkaline conditions in Escherichia coli.PMID 7822245Read ↗

Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli.Semantic proximity Read ↗

pH dependence of the function of sodium ion extrusion systems in Escherichia coli.Semantic proximity Read ↗

NhaA of Escherichia coli, as a model of a pH-regulated Na+/H+antiporter.Semantic proximity Read ↗

Identification and characterization of functional residues in a Na+/H+ antiporter (NhaA) from Escherichia coli by random mutagenesis.Semantic proximity Read ↗

A point mutation (G338S) and its suppressor mutations affect both the pH response of the NhaA-Na+/H+ antiporter as well as the growth phenotype of Escherichia coli.Semantic proximity Read ↗

The Na+ and K+ transport deficiency of an E. coli mutant lacking the NhaA and NhaB proteins is apparent and caused by impaired osmoregulation.Semantic proximity Read ↗

pH-dependent growth retardation of Escherichia coli caused by overproduction of Na+/H+ antiporter.Semantic proximity Read ↗

Regulation of NhaA by protons.Semantic proximity Read ↗

Trans membrane domain IV is involved in ion transport activity and pH regulation of the NhaA-Na(+)/H(+) antiporter of Escherichia coli.Semantic proximity Read ↗

Transmembrane segment II of NhaA Na+/H+ antiporter lines the cation passage, and Asp65 is critical for pH activation of the antiporter.Semantic proximity Read ↗

Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH.Semantic proximity Read ↗

Diversities and similarities in pH dependency among bacterial NhaB-like Na+/H+ antiporters.Semantic proximity Read ↗

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