Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The NhaB Na+/H+ antiporter is essential for intracellular pH regulation under alkaline conditions in Escherichia coli.

Journal of biochemistry - 1 Aug 1994

Shimamoto T, Inaba K, Thelen P, Ishikawa T, Goldberg E B, Tsuda M, Tsuchiya T

Abstract excerpt

We isolated a mutant of Escherichia coli which was defective in an Na+/H+ antiporter and grew poorly under alkaline conditions [Ishikawa, T., Hama, H., Tsuda, T., and Tsuchiya, T. (1987) J. Biol. Chem. 262, 7443-7446]. Later, it was concluded that the defective Na+/H+ antiporter in the mutant was...

Topics

Bacterial Proteins
Escherichia coli
Hydrogen-Ion Concentration
Intracellular Fluid
Mutation
Sodium-Hydrogen Exchangers

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7822245
DOI: 10.1093/oxfordjournals.jbchem.a124521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7822245-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The NhaB Na+/H+ antiporter is essential for intracellular pH regulation under alkaline conditions in Escherichia coli.PMID 7822245Read ↗

Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli.Semantic proximity Read ↗

pH dependence of the function of sodium ion extrusion systems in Escherichia coli.Semantic proximity Read ↗

NhaA of Escherichia coli, as a model of a pH-regulated Na+/H+antiporter.Semantic proximity Read ↗

Identification and characterization of functional residues in a Na+/H+ antiporter (NhaA) from Escherichia coli by random mutagenesis.Semantic proximity Read ↗

A point mutation (G338S) and its suppressor mutations affect both the pH response of the NhaA-Na+/H+ antiporter as well as the growth phenotype of Escherichia coli.Semantic proximity Read ↗

The Na+ and K+ transport deficiency of an E. coli mutant lacking the NhaA and NhaB proteins is apparent and caused by impaired osmoregulation.Semantic proximity Read ↗

pH-dependent growth retardation of Escherichia coli caused by overproduction of Na+/H+ antiporter.Semantic proximity Read ↗

Regulation of NhaA by protons.Semantic proximity Read ↗

Trans membrane domain IV is involved in ion transport activity and pH regulation of the NhaA-Na(+)/H(+) antiporter of Escherichia coli.Semantic proximity Read ↗

Transmembrane segment II of NhaA Na+/H+ antiporter lines the cation passage, and Asp65 is critical for pH activation of the antiporter.Semantic proximity Read ↗

Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH.Semantic proximity Read ↗

Diversities and similarities in pH dependency among bacterial NhaB-like Na+/H+ antiporters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.