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Article

Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli.

Journal of bacteriology - 1 Oct 1991

Thelen P, Tsuchiya T, Goldberg E B

Abstract excerpt

Using in vivo assays, we show that the Na+/H+ antiporter activity of the Escherichia coli mutant HIT-1 is reduced dramatically compared with activity in wild-type cells. An isogenic nhaA (formerly antA) deletion strain, however, is not significantly different from wild type in this respect. We call the locus affecting Na+/H+ antiporter activity of the HIT-1 mutant nhaB. The nhaB activity exhibits no pH dependence...

Topics

Carrier Proteins
Chromosome Mapping
Chromosomes, Bacterial
Escherichia coli
Hydrogen-Ion Concentration
Melibiose
Mutagenesis, Insertional
Mutation
Serine
Sodium
Sodium-Hydrogen Exchangers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transduction, Genetic

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Identifiers

PMID: 1655717
DOI: 10.1128/jb.173.20.6553-6557.1991
PMCID: PMC208992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655717-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli.PMID 1655717Read ↗

A single amino acid substitution (Glu134-->Ala) in NhaR1 increases the inducibility by Na+ of the product of nhaA, a Na+/H+ antiporter gene in Escherichia coli.Semantic proximity Read ↗

The NhaB Na+/H+ antiporter is essential for intracellular pH regulation under alkaline conditions in Escherichia coli.Semantic proximity Read ↗

Identification and characterization of functional residues in a Na+/H+ antiporter (NhaA) from Escherichia coli by random mutagenesis.Semantic proximity Read ↗

NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli.Semantic proximity Read ↗

MH1, a second-site revertant of an Escherichia coli mutant lacking Na+/H+ antiporters (delta nhaA delta nhaB), regains Na+ resistance and a capacity to excrete Na+ in a delta microH(+)-independent fashion.Semantic proximity Read ↗

A point mutation (G338S) and its suppressor mutations affect both the pH response of the NhaA-Na+/H+ antiporter as well as the growth phenotype of Escherichia coli.Semantic proximity Read ↗

NhaA of Escherichia coli, as a model of a pH-regulated Na+/H+antiporter.Semantic proximity Read ↗

NhaA Na+/H+ antiporter mutants that hardly react to the membrane potential.Semantic proximity Read ↗

The Na+ and K+ transport deficiency of an E. coli mutant lacking the NhaA and NhaB proteins is apparent and caused by impaired osmoregulation.Semantic proximity Read ↗

Identification of a pH regulated Na(+)/H(+) antiporter of Methanococcus jannaschii.Semantic proximity Read ↗

Molecular cloning and sequencing of a gene from alkaliphilic Bacillus firmus OF4 that functionally complements an Escherichia coli strain carrying a deletion in the nhaA Na+/H+ antiporter gene.Semantic proximity Read ↗

The evolution of a Na <sup>+</sup> -sensitive <i>Vibrio cholerae</i> mutant unmasks the moonlighting aminopeptidase PepA as a regulator of <i>nhaB</i> Na <sup>+</sup> /H <sup>+</sup> antiporter gene expressionSemantic proximity Read ↗

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