Article
Lithium toxicity and Na+(Li+)/H+ antiporter in Escherichia coli.
Biological & pharmaceutical bulletin - 1 Mar 1994
Inaba K, Kuroda T, Shimamoto T, Kayahara T, Tsuda M, Tsuchiya T
Abstract excerpt
The lithium ion (Li+) shows toxicity against Escherichia coli cells when present in a high concentration in the environment. Since Li+ is extruded from cells via a Na+(Li+)/H+ antiporter, this antiporter must be involved in the detoxification of Li+. Two Na+(Li+)/H+ antiporters (NhaA system and NhaB system) are known to be present in E. coli. We investigated the properties of the antiporters and the participation...
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