In situ detection of frameshift mutations in mouse cells.

doi:10.1016/s0027-5107(98)00163-8

Back to search

Article

In situ detection of frameshift mutations in mouse cells.

Mutation research - 3 Nov 1998

Cao J, DePrimo S E, Hersh M N, Stringer J R

Abstract excerpt

A reporter gene system that allows in situ detection of cells that have suffered a specific frameshift mutation was developed. To construct the reporter gene, the open reading frame of a human placental alkaline phosphatase (PLAP) gene was disrupted by insertion of either 5 or 7 G:C basepairs, wh...

Topics

Alkaline Phosphatase
Alleles
Animals
Base Sequence
Cell Line
DNA
DNA Mutational Analysis
Female
Frameshift Mutation
Genes, Reporter
Humans
Mice
Open Reading Frames
Phenotype
Placenta
Plasmids
Pregnancy
RNA, Messenger

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.