Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene.

Mutation research - 29 Aug 2002

Hersh Megan N, Stambrook Peter J, Stringer James R

Abstract excerpt

To determine the frequency of mutation in different cell types of mammals, transgenic mice that allow mutant cells to be visualized in situ were used. These mice carry a defective allele of the human placental alkaline phosphatase (PLAP) gene. The allele does not produce enzyme because the reading frame is shifted by an insertion of 7 G:C basepairs. The insertion is adjacent to four existing G:C basepairs, so the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzothiazoles
Share to Diamines
Share to Mismatch Repair Endonuclease PMS2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organic Chemicals

Share to Organophosphorus Compounds

Share to Quinazolinones

Share to Quinolines

Share to Staining and Labeling

Source

Identifiers

PMID: 12175905
DOI: 10.1016/s0027-5107(02)00120-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene.PMID 12175905Read ↗

Use of human placental alkaline phosphatase transgenes to detect somatic mutation in mice in situ.Semantic proximity Read ↗

Mutation in aging mice occurs in diverse cell types that proliferate postmutation.Semantic proximity Read ↗

Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging.Semantic proximity Read ↗

Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.Semantic proximity Read ↗

In situ detection of frameshift mutations in mouse cells.Semantic proximity Read ↗

Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk(+/-) transgenic mice.Semantic proximity Read ↗

Modeling variation in tumors in vivo.Semantic proximity Read ↗

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.Semantic proximity Read ↗

Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys.Semantic proximity Read ↗

High Mutation Levels are Compatible with Normal Embryonic Development in Mlh1-Deficient Mice.Semantic proximity Read ↗

Tumors arising in DNA mismatch repair-deficient mice show a wide variation in mutation frequency as assessed by a transgenic reporter gene.Semantic proximity Read ↗

Role of the Msh2 gene in genome maintenance and development in mouse fetuses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.