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Article

Modeling variation in tumors in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2005

Stringer James R, Larson Jon S, Fischer Jared M, Medvedovic Mario, Hersh Megan N, Boivin Gregory P, Stringer Saundra L

Abstract excerpt

Transgenic mice that allow mutant cells to be visualized in situ were used to study variation in tumors. These mice carry the G11 placental alkaline phosphatase (PLAP) transgene, a mutant allele rendered incapable of producing its enzyme product by a frameshift caused by insertion of a tract of G:C base pairs in a coding region. Spontaneous deletion of one G:C base pair from this tract restores gene function, and...

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Identifiers

PMID: 15695337
DOI: 10.1073/pnas.0401340102
PMCID: PMC548963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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