Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Use of human placental alkaline phosphatase transgenes to detect somatic mutation in mice in situ.

Methods (San Diego, Calif.) - 1 Sept 1998

DePrimo S E, Cao J, Hersh M N, Stringer J R

Abstract excerpt

Methods for in situ detection of cells that have suffered a specific mutation would be valuable for understanding somatic genetic mosaicism, a phenomenon that underlies a variety of diseases including cancer. Such methods would also be valuable in studying changes in gene expression, whether programmed by the cells or caused by exogenous forces, such as exposure to genotoxins or infection by a virus. To improve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Gene Expression Regulation, Enzymologic
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutagenesis

Share to Phenotype

Share to Plasmids

Source

Identifiers

PMID: 9774516
DOI: 10.1006/meth.1998.0644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Use of human placental alkaline phosphatase transgenes to detect somatic mutation in mice in situ.PMID 9774516Read ↗

In situ detection of frameshift mutations in mouse cells.Semantic proximity Read ↗

Modeling variation in tumors in vivo.Semantic proximity Read ↗

Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene.Semantic proximity Read ↗

The mechanism of somatic hypermutation studied with transgenic and transfected target genes.Semantic proximity Read ↗

Analysis of somatic mutation with a reporter gene construct.Semantic proximity Read ↗

Mutation in aging mice occurs in diverse cell types that proliferate postmutation.Semantic proximity Read ↗

Creation of Mice Bearing a Partial Duplication of HPRT Gene Marked with a GFP Gene and Detection of Revertant Cells In Situ as GFP-Positive Somatic Cells.Semantic proximity Read ↗

On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice.Semantic proximity Read ↗

Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids.Semantic proximity Read ↗

Comparison of somatic mutation in a transgenic versus host locus.Semantic proximity Read ↗

Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids.Semantic proximity Read ↗

Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.