Deletion-pattern analysis of alpha-particle and X-ray induced mutations at the HPRT locus of V79 Chinese hamster cells.

doi:10.1016/s0027-5107(98)00159-6

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Article

Deletion-pattern analysis of alpha-particle and X-ray induced mutations at the HPRT locus of V79 Chinese hamster cells.

Mutation research - 3 Nov 1998

Schmidt P, Kiefer J

Abstract excerpt

To investigate the mutagenic mechanisms of low-energy alpha particles V79 Chinese hamster cells were irradiated with 241Am-alpha particles (mean LET of 112 keV/micron). Parallel experiments were performed using 300 kV X-rays. Cell inactivation and mutation induction cross sections were measured....

Topics

Alpha Particles
Animals
Cell Line
Cell Survival
Cricetinae
Cricetulus
DNA Damage
DNA Mutational Analysis
Exons
Hypoxanthine Phosphoribosyltransferase
Mutation
Polymerase Chain Reaction
Sequence Deletion
X-Rays

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