Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect.

Radiation research - 1 Nov 1999

Nagasawa H, Little J B

Abstract excerpt

We examined the induction of HPRT mutations in CHO cells exposed to low fluences of (238)Pu alpha particles from a specially constructed irradiator. The dose-response relationship was linear over the dose range of 5 cGy-1.2 Gy. However, unexpected sensitivity, leading to a significantly higher frequency of mutations than would be predicted by a back extrapolation from the data for higher doses, was observed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alpha Particles
Share to Apoptosis
Share to Cell Survival

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CHO Cells

Share to Cricetinae

Share to Dose-Response Relationship, Radiation

Share to Hypoxanthine Phosphoribosyltransferase

Share to Mutation

Source

Identifiers

PMID: 10521933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect.PMID 10521933Read ↗

Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells.Semantic proximity Read ↗

Mutagenic effects of a single and an exact number of alpha particles in mammalian cells.Semantic proximity Read ↗

Radiation risk to low fluences of alpha particles may be greater than we thought.Semantic proximity Read ↗

Dose-dependent changes in the spectrum of mutations induced by ionizing radiation.Semantic proximity Read ↗

Multiplex polymerase chain reaction-based deletion analysis of spontaneous, gamma ray- and alpha-induced hprt mutants of CHO-K1 cells.Semantic proximity Read ↗

Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles.Semantic proximity Read ↗

Relative biological effect of alpha particle radiation on low dose phenomena: lethal mutation, hyper-radiosensitivity and increased radioresistanceSemantic proximity Read ↗

Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation.Semantic proximity Read ↗

Deletion-pattern analysis of alpha-particle and X-ray induced mutations at the HPRT locus of V79 Chinese hamster cells.Semantic proximity Read ↗

Induction of somatic mutations by low-dose X-rays: the challenge in recognizing radiation-induced events.Semantic proximity Read ↗

Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells.Semantic proximity Read ↗

Mutation induction by different types of radiation at the Hprt locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.