Article
Induction of HPRT- mutants in Chinese hamster V79 cells after heavy ion exposure.
Radiation and environmental biophysics - 1 Jun 1995
Stoll U, Schneider E, Kranert T, Kiefer J
Abstract excerpt
The induction of resistance to 6-thioguanine by heavy ion exposure was investigated with various accelerated ions (oxygen-uranium) up to linear energy transfer (LET) values of about 15,000 keV/microns. Survival curves are exponential with fluence; mutation induction shows a linear dependence. Cross-sections (sigma i: inactivation, sigma m: mutation) were derived from the respective slopes. Generally, sigma i...
Topics
- Animals
- Cells, Cultured
- Cricetinae
- Cricetulus
- Hypoxanthine Phosphoribosyltransferase
- Linear Energy Transfer
- Mutation
