An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer.

Article

An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer.

Cancer research - 1 Apr 1997

Zhang Q X, Borg A, Wolf D M, Oesterreich S, Fuqua S A

Abstract excerpt

Thirty tumors from metastatic breast cancer patients were screened for mutations in the estrogen receptor (ER) gene using single-strand conformation polymorphism and sequence analysis. Three missense mutations, Ser47Thr, Lys531Glu, and Tyr537Asn, were identified in these lesions. To investigate t...

Topics

Breast Neoplasms
Estradiol
Female
HeLa Cells
Humans
Models, Genetic
Mutation
Neoplasm Metastasis
Polymorphism, Single-Stranded Conformational
Receptors, Estrogen
Tamoxifen
Transcription, Genetic
Transfection

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