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Article

An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer.

Cancer research - 1 Apr 1997

Zhang Q X, Borg A, Wolf D M, Oesterreich S, Fuqua S A

Abstract excerpt

Thirty tumors from metastatic breast cancer patients were screened for mutations in the estrogen receptor (ER) gene using single-strand conformation polymorphism and sequence analysis. Three missense mutations, Ser47Thr, Lys531Glu, and Tyr537Asn, were identified in these lesions. To investigate these mutated ERs or altered transcriptional activation function, expression vectors containing wild-type (wt) and...

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PMID: 9102207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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