Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma.

doi:10.1210/jcem.83.12.5345

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Article

Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma.

The Journal of clinical endocrinology and metabolism - 1 Dec 1998

Eng C, Thomas G A, Neuberg D S, Mulligan L M, Healey C S, Houghton C, Frilling A, Raue F, Williams E D, Ponder B A

Abstract excerpt

Mutations in the RET proto-oncogene, which encodes a receptor tyrosine kinase, are associated with the pathogenesis of medullary thyroid carcinoma (MTC). Somatic mutations in RET, predominantly at codon 918, and very rarely at codon 883, have been found in a proportion of sporadic MTC. We have pr...

Topics

Carcinoma, Medullary
Drosophila Proteins
Humans
Immunohistochemistry
Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases
Thyroid Neoplasms

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PMID: 9851769
DOI: 10.1210/jcem.83.12.5345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9851769-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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