Article
High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas.
The Journal of clinical endocrinology and metabolism - 1 May 2011
Moura Margarida M, Cavaco Branca M, Pinto António E, Leite Valeriano
Abstract excerpt
CONTEXT: Sporadic medullary thyroid carcinomas (MTC) frequently harbor mutations in the RET protooncogene. We have earlier reported a series of 51 sporadic MTC with 64.7% of RET-positive and 35.3% of RET-negative cases. OBJECTIVE: In the present study, we investigated the possible involvement of RAS and BRAF protooncogenes in the development of sporadic RET-negative MTC. PATIENTS AND DESIGN: We performed PCR...
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