Article
Genetic studies and molecular markers of bladder cancer.
Seminars in surgical oncology - 1 Jan 2000
Cordon-Cardo C, Sheinfeld J, Dalbagni G
Abstract excerpt
Target genes implicated in cellular transformation and tumor progression have been divided into two categories: proto-oncogenes which, when activated, become dominant events characterized by the gain of function, and tumor suppressor genes which become recessive events characterized by the loss of function. Alterations in proto-oncogenes and tumor suppressor genes seem equally prevalent among human cancers....
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