Article
p53 and retinoblastoma pathways in bladder cancer.
World journal of urology - 1 Dec 2007
Mitra Anirban P, Birkhahn Marc, Cote Richard J
Abstract excerpt
A majority of the aggressive, invasive bladder carcinomas have alterations in the p53 and retinoblastoma genes and pathways. Examination of the alterations in the molecules in these pathways that regulate the cell cycle and their effects on the prognosis of bladder cancer are areas of active research. While defects in the p53-Mdm2-p14 axis have been implicated in urothelial cancer, perturbations in the...
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