Article
Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.
Neurobiology of disease - 1 Oct 1998
De Jonghe C, Zehr C, Yager D, Prada C M, Younkin S, Hendriks L, Van Broeckhoven C, Eckman C B
Abstract excerpt
Mutations in the amyloid beta precursor protein (APP) gene cosegregate with autosomal dominant Alzheimer disease (AD). Brain pathology of AD is characterized by amyloid deposition in senile plaques and by neurofibrillary tangles. Amyloid deposits in AD brains consist of amyloid beta (A beta), a 4-kDa proteolytic product of APP. In contrast, two other mutations in APP, the Flemish APP692 and Dutch APP693...
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