Article
Hereditary cerebral hemorrhage with amyloidosis Dutch type (AbetaPP 693): decreased plasma amyloid-beta 42 concentration.
Neurobiology of disease - 1 Dec 2003
Bornebroek Marjolijn, De Jonghe Chris, Haan Joost, Kumar-Singh Samir, Younkin Steve, Roos Raymund, Van Broeckhoven Christine
Abstract excerpt
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is a rare autosomal dominant disorder caused by an amyloid-beta precursor protein (AbetaPP) 693 mutation that clinically leads to recurrent hemorrhagic strokes and dementia. The disease is pathologically characterised by the deposition of Abeta in cerebral blood vessels and as plaques in the brain parenchyma. This study measured the Abeta40 and...
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