Article
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
The Journal of biological chemistry - 1 Jul 1994
Haass C, Hung A Y, Selkoe D J, Teplow D B
Abstract excerpt
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the extracellular deposition of amyloid beta-protein (A beta), a molecule produced by post-translational processing of the beta-amyloid precursor protein (beta APP). Mutations within the gene encoding beta APP h...
Topics
- Alanine
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Protein Precursor
- Base Sequence
- Cells, Cultured
- Chromosome Mapping
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Phenylalanine
- Protein Processing, Post-Translational
- Transfection