Article
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
Nature - 17 Dec 1992
Citron M, Oltersdorf T, Haass C, McConlogue L, Hung A Y, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe D J
Abstract excerpt
Progressive cerebral deposition of the 39-43-amino-acid amyloid beta-protein (A beta) is an invariant feature of Alzheimer's disease which precedes symptoms of dementia by years or decades. The only specific molecular defects that cause Alzheimer's disease which have been identified so far are missense mutations in the gene encoding the beta-amyloid precursor protein (beta-APP) in certain families with an...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Base Sequence
- Cell Line
- Humans
- Kidney
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides