Article
Molecular biology of Alzheimer's amyloid--Dutch variant.
Molecular neurobiology - 1 Jan 1992
Wisniewski T, Frangione B
Abstract excerpt
Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D) (or familial cerebral amyloid angiopathy) and familial Alzheimer's disease (FAD) share several properties. Both are autosomal dominant forms of cerebral amyloidosis characterized by beta-amyloid (A beta) deposition. In HCHWA-D the A beta is predominantly found in blood vessels and in early parenchymal plaques, whereas in AD parenchymal A beta...
Topics
- Alzheimer Disease
- Amyloid
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Cerebral Amyloid Angiopathy
- Codon
- Exons
- Genes, Dominant
- Humans
- Middle Aged
- Mutation
- Netherlands