Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric sindbis viruses.

doi:10.1128/JVI.73.1.561-575.1999

Back to search

Article

Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric sindbis viruses.

Journal of virology - 1 Jan 1999

Filocamo G, Pacini L, Nardi C, Bartholomew L, Scaturro M, Delmastro P, Tramontano A, De Francesco R, Migliaccio G

Abstract excerpt

The NS3-NS4A serine protease of hepatitis C virus (HCV) mediates four specific cleavages of the viral polyprotein and its activity is considered essential for the biogenesis of the HCV replication machinery. Despite extensive biochemical and structural characterization, the analysis of natural va...

Topics

Animals
Cricetinae
Hepacivirus
Mice
Mutation
Recombinant Fusion Proteins
Sindbis Virus
Viral Nonstructural Proteins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.