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Article

Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin.

PLoS pathogens - 1 May 2015

Bergeron Éric, Zivcec Marko, Chakrabarti Ayan K, Nichol Stuart T, Albariño César G, Spiropoulou Christina F

Abstract excerpt

Crimean Congo hemorrhagic fever virus (CCHFV) is a negative-strand RNA virus of the family Bunyaviridae (genus: Nairovirus). In humans, CCHFV causes fever, hemorrhage, severe thrombocytopenia, and high fatality. A major impediment in precisely determining the basis of CCHFV's high pathogenicity has been the lack of methodology to produce recombinant CCHFV. We developed a reverse genetics system based on...

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PMID: 25933376
DOI: 10.1371/journal.ppat.1004879
PMCID: PMC4416775

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RSKR

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