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Article

Semliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots.

Journal of virology - 27 Sept 2021

Teppor Mona, Žusinaite Eva, Karo-Astover Liis, Omler Ailar, Rausalu Kai, Lulla Valeria, Lulla Aleksei, Merits Andres

Abstract excerpt

Alphaviruses (family Togaviridae) include both human pathogens such as chikungunya virus (CHIKV) and Sindbis virus (SINV) and model viruses such as Semliki Forest virus (SFV). The alphavirus positive-strand RNA genome is translated into nonstructural (ns) polyprotein(s) that are precursors for four nonstructural proteins (nsPs). The three-dimensional structures of nsP2 and the N-terminal 2/3 of nsP3 reveal that...

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Identifiers

PMID: 34319778
DOI: 10.1128/JVI.00973-21
PMCID: PMC8475518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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