Article
Mutation detection by ligation to complete n-mer DNA arrays.
Genome research - 1 Nov 1998
Gunderson K L, Huang X C, Morris M S, Lipshutz R J, Lockhart D J, Chee M S
Abstract excerpt
A new approach to comparative nucleic acid sequence analysis is described that uses the ligation of DNA targets to high-density arrays containing complete sets of covalently attached oligonucleotides of length eight and nine. The combination of enzymatic or chemical ligation with a directed compa...
Topics
- Base Sequence
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA
- DNA Ligases
- DNA Mutational Analysis
- DNA Probes
- Genes, p53
- Mutation
- Oligonucleotide Array Sequence Analysis