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Capillary and microelectrophoretic separations of ligase detection reaction products produced from low-abundant point mutations in genomic DNA.

Electrophoresis - 1 Jun 2004

Thomas Gloria, Sinville Rondedrick, Sutton Shelby, Farquar Hannah, Hammer Robert P, Soper Steven A, Cheng Yu-Wei, Barany Francis

Abstract excerpt

Capillary gel electrophoresis (CGE) and polymer-based microelectrophoretic platforms were investigated to analyze low-abundant point mutations in certain gene fragments with high diagnostic value for colorectal cancers. The electrophoretic separations were carried out on single-stranded DNA (ssDNA) products generated from an allele-specific ligation assay (ligase detection reaction, LDR), which was used to screen...

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PMID: 15188256
DOI: 10.1002/elps.200405886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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