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Article

Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex.

Immunity - 1 Nov 1998

Zuberi A R, Christianson G J, Mendoza L M, Shastri N, Roopenian D C

Abstract excerpt

Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cells to identify the H3a gene responsible for immunodominant H2-Db-restricted determinants of the...

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PMID: 9846490
DOI: 10.1016/s1074-7613(00)80666-4

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