Article
Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex.
Immunity - 1 Nov 1998
Zuberi A R, Christianson G J, Mendoza L M, Shastri N, Roopenian D C
Abstract excerpt
Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capabil...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Calpain
- Chromosome Mapping
- Cloning, Molecular
- DNA-Binding Proteins
- Immunodominant Epitopes
- Loss of Heterozygosity
- Mice
- Mice, Inbred C57BL
- Minor Histocompatibility Antigens
- Minor Histocompatibility Loci
- Molecular Sequence Data
- Muscle Proteins
- Peptide Fragments