Article
Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.
Immunity - 15 Aug 2017
Denzin Lisa K, Khan Aly A, Virdis Francesca, Wilks Jessica, Kane Melissa, Beilinson Helen A, Dikiy Stanislav, Case Laure K, Roopenian Derry, Witkowski Michele, Chervonsky Alexander V, Golovkina Tatyana V
Abstract excerpt
Select humans and animals control persistent viral infections via adaptive immune responses that include production of neutralizing antibodies. The precise genetic basis for the control remains enigmatic. Here, we report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ strain. It encodes the beta subunit of the non-classical major...
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