Article
TCR selection and allelic exclusion in RAG transgenic mice that exhibit abnormal T cell localization in lymph nodes and lymphatics.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1994
Wayne J, Suh H, Sokol K A, Petrie H T, Witmer-Pack M, Edelhoff S, Disteche C M, Nussenzweig M C
Abstract excerpt
RAG-1 and RAG-2 are developmentally regulated genes that are essential for V(D)J recombination and lymphocyte development. Expression of RAG-1 and RAG-2 by thymocytes is normally limited to cells that have not completed selection. We have previously documented that persistent expression of the recombinase activating genes (RAG) in transgenic mice results in aberrant thymic development, altered lymphatic...
Topics
- Alleles
- Animals
- DNA-Binding Proteins
- Flow Cytometry
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Homeodomain Proteins
- Liver
- Lymph Nodes
- Lymphatic System
- Mice