Article
A novel role for p21-activated protein kinase 2 in T cell activation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2004
Chu Peter C, Wu Jun, Liao X Charlene, Pardo Jorge, Zhao Haoran, Li Congfen, Mendenhall Marcy K, Pali Erlina, Shen Mary, Yu Simon, Taylor Vanessa C, Aversa Gregorio, Molineaux Susan, Payan Donald G, Masuda Esteban S
Abstract excerpt
To identify novel components of the TCR signaling pathway, a large-scale retroviral-based functional screen was performed using CD69 expression as a marker for T cell activation. In addition to known regulators, two truncated forms of p21-activated kinase 2 (PAK2), PAK2DeltaL(1-224) and PAK2DeltaS(1-113), both lacking the kinase domain, were isolated in the T cell screen. The PAK2 truncation, PAK2DeltaL, blocked...
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