[Evaluation of yeast functional assay to detect p53 gene mutation in minute endoscopic samples of colonic mucosal neoplasia].

Article

[Evaluation of yeast functional assay to detect p53 gene mutation in minute endoscopic samples of colonic mucosal neoplasia].

[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 Sept 1998

Nakamura Y

Abstract excerpt

Mutation in the p53 tumor suppressor gene is known to play a critical role in the carcinogenesis of many types of human cancers, especially in colon carcinogenesis. To investigate the early stage of neoplastic processes, a simple and reliable method is needed to evaluate the state of p53 mutation...

Topics

Adenocarcinoma
Aged
Aged, 80 and over
Colonic Neoplasms
DNA Mutational Analysis
Female
Genes, p53
Humans
Male
Middle Aged
Mutation
Saccharomyces cerevisiae
Tumor Cells, Cultured

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