Article
Selective detection of inactivating mutations of the tumor suppressor gene p53 in bladder tumors.
The Journal of urology - 1 Jun 1999
Pfister C, Flaman J M, Martin C, Grise P, Frebourg T
Abstract excerpt
OBJECTIVE: Mutations in the p53 gene are implicated in the pathogenesis of half of all human tumors. In bladder tumors they are usually detected by immunohistochemistry. The assumption underlying protein analysis is that high level p53 expression is a consequence of mutations, but numerous exceptions have been reported. We describe the detection of p53 mutations in bladder cancer using a functional assay in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.