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Detection of P53 abnormalities in non-small cell lung cancer by yeast functional assay.

Folia histochemica et cytobiologica - 1 Jan 2001

Niklinska W, Chyczewski L, Laudanski J, Sawicki B, Niklinski J

Abstract excerpt

We assessed the status of P53 in 32 surgically treated non-small cell lung cancers (NSCLC) by using yeast functional assay. For functional assay, total RNA extracted from fresh-frozen specimens was reverse transcribed and P53 cDNAs were PCR-amplified using Pfu DNA polymerase (Stratagene). The transcriptional competence of the P53 cDNA was then tested in a yeast reporter strain. 20 of the 32 (69%) NSCLC patients...

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PMID: 11374799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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