Article
[Establishment of mouse p53 yeast functional assay and evaluation of its detectability of p53 gene mutation].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 Jul 1999
Tsunematsu I
Abstract excerpt
Mice have widely been used as an experimental model for carcinogenesis induced by chemicals or irradiation. Recently, transgenic mice expressing oncogene proteins and knockout mice lacking for tumor suppressor genes are available, and used for the analysis of mechanisms underlying carcinogenesis. In such experimental carcinogenesis, a rapid and sensitive method for screening p53 mutations is desired. In human...
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