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Article

[Significance of p53 gene abnormalities in carcinogenesis of human gastrointestinal tract].

Nihon Geka Gakkai zasshi - 1 Sept 1992

Tahara E, Yokozaki H

Abstract excerpt

Allelic loss and mutation of the p53 gene are common events of esophageal, gastric and colorectal cancers occurring from an early stage. Moreover, p53 mutation takes place in intestinal metaplasia and adenoma of the stomach. p53 mutation spectra differ among esophageal, gastric and colorectal cancers suggesting exposure to different endogenous and exogenous mutagens. The in vivo and in vitro results indicate that...

Topics

Chromosome Deletion
Colorectal Neoplasms
Esophageal Neoplasms
Gastrointestinal Neoplasms
Genes, p53
Humans
Mutation
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1470160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1470160-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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