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Article

Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.

Diabetic medicine : a journal of the British Diabetic Association - 1 Mar 2004

Tait K F, Collins J E, Heward J M, Eaves I, Snook H, Franklyn J A, Barnett A H, Todd J A, Maranian M, Compston A, Sawcer S, Gough S C L

Abstract excerpt

AIMS: The Type 1 diabetes susceptibility locus, IDDM2, has been mapped to a variable number of tandem repeats (VNTR) region 5' upstream of the insulin (INS) and insulin-like growth factor (IGF2) genes on chromosome 11p15. The function of the VNTR is uncertain; however, it may influence the thymic expression of the insulin gene and affect the development of immune self-tolerance. The aim of this study was to...

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Source

Identifiers

PMID: 15008838
DOI: 10.1111/j.1464-5491.2004.01129.x

Genes

INS
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.PMID 15008838Read ↗

IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.Semantic proximity Read ↗

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.Semantic proximity Read ↗

Autoimmune responses to the beta cell autoantigen, insulin, and the INS VNTR-IDDM2 locus.Semantic proximity Read ↗

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.Semantic proximity Read ↗

Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II.Semantic proximity Read ↗

Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes.Semantic proximity Read ↗

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Semantic proximity Read ↗

No association of INS-VNTR genotype and IAA autoantibodies.Semantic proximity Read ↗

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.Semantic proximity Read ↗

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.Semantic proximity Read ↗

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

Major histocompatibility class II genes polymorphism in insulin dependent diabetes mellitus with or without associated thyroid autoimmunity.Semantic proximity Read ↗

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