Article
Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II.
BMC medical genetics - 11 Jul 2008
Ramos-Lopez Elizabeth, Lange Britta, Kahles Heinrich, Willenberg Holger S, Meyer Gesine, Penna-Martinez Marissa, Reisch Nicole, Hahner Stefanie, Seissler Jürgen, Badenhoop Klaus
Abstract excerpt
BACKGROUND: Polymorphisms within the insulin gene can influence insulin expression in the pancreas and especially in the thymus, where self-antigens are processed, shaping the T cell repertoire into selftolerance, a process that protects from beta-cell autoimmunity. METHODS: We investigated the role of the -2221Msp(C/T) and -23HphI(A/T) polymorphisms within the insulin gene in patients with a monoglandular...
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