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Article

No association of INS-VNTR genotype and IAA autoantibodies.

Annals of the New York Academy of Sciences - 1 Dec 2004

Pérez de Nanclares Guiomar, Bilbao J Ramón, Castano Luis

Abstract excerpt

Type 1 diabetes is associated with autoimmune responses against insulin, with insulin autoantibodies (IAA) being a hallmark of the disease. Genetic susceptibility to type 1 diabetes is polygenic and includes the INS VNTR-IDDM2 locus, which has been shown to regulate the expression of insulin in the pancreas and thymus. In order to determine whether insulin autoimmunity could be attributed to a genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15699505
DOI: 10.1196/annals.1337.020

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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No association of INS-VNTR genotype and IAA autoantibodies.PMID 15699505Read ↗

Autoimmune responses to the beta cell autoantigen, insulin, and the INS VNTR-IDDM2 locus.Semantic proximity Read ↗

Insulin VNTR I/III genotype is associated with autoantibodies against glutamic acid decarboxylase in newly diagnosed type 1 diabetes.Semantic proximity Read ↗

Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.Semantic proximity Read ↗

Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry.Semantic proximity Read ↗

Polymorphism in gene for islet autoantigen, IA-2, and type 1 diabetes in Japanese subjects.Semantic proximity Read ↗

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.Semantic proximity Read ↗

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Semantic proximity Read ↗

Autoantibodies and HLA susceptibility markers in Canadian first-degree relatives of patients with type 1 diabetes.Semantic proximity Read ↗

Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.Semantic proximity Read ↗

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.Semantic proximity Read ↗

Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes.Semantic proximity Read ↗

Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.Semantic proximity Read ↗

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