Article
Islet autoimmunity identifies a unique pattern of impaired pancreatic beta-cell function, markedly reduced pancreatic beta cell mass and insulin resistance in clinically diagnosed type 2 diabetes.
PloS one - 1 Jan 2014
Subauste Angela, Gianani Roberto, Chang Annette M, Plunkett Cynthia, Pietropaolo Susan L, Zhang Ying-Jian, Barinas-Mitchell Emma, Kuller Lewis H, Galecki Andrzej, Halter Jeffrey B, Pietropaolo Massimo
Abstract excerpt
There is a paucity of literature describing metabolic and histological data in adult-onset autoimmune diabetes. This subgroup of diabetes mellitus affects at least 5% of clinically diagnosed type 2 diabetic patients (T2DM) and it is termed Latent Autoimmune Diabetes in Adults (LADA). We evaluated indexes of insulin secretion, metabolic assessment, and pancreatic pathology in clinically diagnosed T2DM patients...
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