Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents.

doi:10.1073/pnas.95.25.14967

Back to search

Article

Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998

Goldman D L, Fries B C, Franzot S P, Montella L, Casadevall A

Abstract excerpt

High-frequency reversible changes in colony morphology were observed in three strains of Cryptococcus neoformans. For one strain (SB4, serotype A), this process produced three colony types: smooth (S), wrinkled (W), and serrated (C). The frequency of switching between colony types varied for the...

Topics

Animals
Cryptococcosis
Cryptococcus neoformans
Humans
Inflammation
Mice
Phenotype
Rats
Virulence

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.