Article
Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998
Goldman D L, Fries B C, Franzot S P, Montella L, Casadevall A
Abstract excerpt
High-frequency reversible changes in colony morphology were observed in three strains of Cryptococcus neoformans. For one strain (SB4, serotype A), this process produced three colony types: smooth (S), wrinkled (W), and serrated (C). The frequency of switching between colony types varied for the individual colony transitions and was as high as 10(-3). Mice infected with colony type W died faster than those...
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