Article
Phenotypic switching of Cryptococcus neoformans occurs in vivo and influences the outcome of infection.
The Journal of clinical investigation - 1 Dec 2001
Fries B C, Taborda C P, Serfass E, Casadevall A
Abstract excerpt
Phenotypic switching has been linked to the virulence of many pathogens, including fungi. However, it has not been conclusively shown to occur in vivo or to influence the outcome of infection. Cryptococcus neoformans undergoes phenotypic switching in vitro to colony types that differ in their virulence in mice. In this study, we asked whether C. neoformans undergoes phenotypic switching in vivo and whether this...
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