Article
Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomallei.
Journal of bacteriology - 1 Feb 2007
Chantratita Narisara, Wuthiekanun Vanaporn, Boonbumrung Khaemaporn, Tiyawisutsri Rachaneeporn, Vesaratchavest Mongkol, Limmathurotsakul Direk, Chierakul Wirongrong, Wongratanacheewin Surasakdi, Pukritiyakamee Sasithorn, White Nicholas J, Day Nicholas P J, Peacock Sharon J
Abstract excerpt
Melioidosis is a notoriously protracted illness and is difficult to cure. We hypothesize that the causative organism, Burkholderia pseudomallei, undergoes a process of adaptation involving altered expression of surface determinants which facilitates persistence in vivo and that this is reflected by changes in colony morphology. A colony morphotyping scheme and typing algorithm were developed using clinical B....
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